AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion During Zebrafish Heart Regeneration.

ABSTRACT:

Rationale

The adult human heart is an organ with low regenerative potential. Heart failure following acute myocardial infarction is a leading cause of death due to the inability of cardiomyocytes to proliferate and replenish lost cardiac muscle. While the zebrafish has emerged as a powerful model to study endogenous cardiac regeneration, the molecular mechanisms by which cardiomyocytes respond to damage by disassembling sarcomeres, proliferating, and repopulating the injured area remain unclear. Furthermore, we are far from understanding the regulation of the chromatin landscape and epigenetic barriers that must be overcome for cardiac regeneration to occur.

Objective

To identify transcription factor regulators of the chromatin landscape, which promote cardiomyocyte regenera

SUBMITTER: Beisaw A 

PROVIDER: S-EPMC7274905 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature