NAT1 genetic variation increases asthma risk in children with secondhand smoke exposure.

ABSTRACT:

Objective

We previously reported that children exposed to secondhand smoke (SHS) that carried variants in the NAT1 gene had over two-fold higher hair cotinine levels. Our objective was to determine if NAT1 polymorphisms confer increased risk for developing asthma in children exposed to SHS.

Methods

White participants in the Cincinnati Childhood Allergy and Air Pollution Study (n = 359) were genotyped for 10 NAT1 variants. Smoke exposure was defined by hair cotinine and parental report. Asthma was objectively assessed by spirometry and methacholine challenge. Findings were replicated in the Genomic Control Cohort (n = 638).

Results

Significant associations between 5 NAT1 variants and asthma were observed in the CCAAPS exposed group compared

SUBMITTER: Brooks CC 

PROVIDER: S-EPMC7274907 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature