MRI vastus lateralis fat fraction predicts loss of ambulation in Duchenne muscular dystrophy.

ABSTRACT: OBJECTIVE:We studied the potential of quantitative MRI (qMRI) as a surrogate endpoint in Duchenne muscular dystrophy by assessing the additive predictive value of vastus lateralis (VL) fat fraction (FF) to age on loss of ambulation (LoA). METHODS:VL FFs were determined on longitudinal Dixon MRI scans from 2 natural history studies in Leiden University Medical Center (LUMC) and Cincinnati Children's Hospital Medical Center (CCHMC). CCHMC included ambulant patients, while LUMC included a mixed ambulant and nonambulant population. We fitted longitudinal VL FF values to a sigmoidal curve using a mixed model with random slope to predict individual trajectories. The additive value of VL FF over age to predict LoA was calculated from a Cox model, yielding a hazard ratio. RESULTS:Eighty-nine MRIs

SUBMITTER: Naarding KJ 

PROVIDER: S-EPMC7274919 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature