Simple MRI score aids prediction of dementia in cerebral small vessel disease.

ABSTRACT:

Objective

To determine whether a simple small vessel disease (SVD) score, which uses information available on rapid visual assessment of clinical MRI scans, predicts risk of cognitive decline and dementia, above that provided by simple clinical measures.

Methods

Three prospective longitudinal cohort studies (SCANS [St George's Cognition and Neuroimaging in Stroke], RUN DMC [Radboud University Nijmegen Diffusion Imaging and Magnetic Resonance Imaging Cohort], and the ASPS [Austrian Stroke Prevention Study]), which covered a range of SVD severity from mild and asymptomatic to severe and symptomatic, were included. In all studies, MRI was performed at baseline, cognitive tests repeated during follow-up, and progression to dementia recorded prospectively. Outcome measures were c

SUBMITTER: Amin Al Olama A 

PROVIDER: S-EPMC7274929 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature