Investigation of monoterpenoid resistance mechanisms in Pseudomonas putida and their consequences for biotransformations.

ABSTRACT: Monoterpenoids are widely used in industrial applications, e.g. as active ingredients in pharmaceuticals, in flavor and fragrance compositions, and in agriculture. Severe toxic effects are known for some monoterpenoids making them challenging compounds for biotechnological production processes. Some strains of the bacterium Pseudomonas putida show an inherent extraordinarily high tolerance towards solvents including monoterpenoids. An understanding of the underlying factors can help to create suitable strains for monoterpenoids de novo production or conversion. In addition, knowledge about tolerance mechanisms could allow a deeper insight into how bacteria can oppose monoterpenoid containing drugs, like tea tree oil. Within this work, the resistance mechanisms of P. putida GS1 were investi

SUBMITTER: Schempp FM 

PROVIDER: S-EPMC7275096 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature