Genetic Profiles Playing Opposite Roles of Pathogenesis in Schizophrenia and Glioma.

ABSTRACT:

Background

Patients diagnosed with schizophrenia were found having lower risks to develop cancers, including glioma. Based on this epidemiology, we hypothesized that there were gene profiles playing opposite roles in pathogenesis of schizophrenia and glioma.

Methods

Based on GEO datasets and TCGA, key genes of schizophrenia genes on the opposite development of glioma were screened by different expressed genes (DEGs) screening, weighted gene coexpression network analysis (WGCNA), disease-specific survival (DSS), and glioma grading and verified by gene set enrichment analysis (GSEA).

Results

First, 612 DEGs were screened from schizophrenia and control brain samples. Second, 134 key genes more specific to schizophrenia were left by WGCNA, with 93 key genes having annotat

SUBMITTER: Wen YD 

PROVIDER: S-EPMC7275202 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature