Oleic acid and derivatives affect human endothelial cell mitochondrial function and vasoactive mediator production.

ABSTRACT:

Background

Inhalation of common air pollutants such as diesel and biodiesel combustion products can induce vascular changes in humans which may contribute to increased mortality and morbidity associated with fine particulate matter exposures. Diesel, biodiesel, and other combustion byproducts contain fatty acid components capable of entering the body through particulate matter inhalation. Fatty acids can also be endogenously released into circulation following a systemic stress response to some inhaled pollutants such as ozone. When in the circulation, bioactive fatty acids may interact with cells lining the blood vessels, potentially inducing endothelial dysfunction. To examine whether fatty acids could potentially be involved in human vascular responses to air pollutants, we dete

SUBMITTER: Bass VL 

PROVIDER: S-EPMC7275404 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature