808 nm-activable core@multishell upconverting nanoparticles with enhanced stability for efficient photodynamic therapy.

ABSTRACT:

Background

The unique upconversion properties of rare-earth-doped nanoparticles offers exciting opportunities for biomedical applications, in which near-IR remote activation of biological processes is desired, including in vivo bioimaging, optogenetics, and light-based therapies. Tuning of upconversion in purposely designed core-shell nanoparticles gives access to biological windows in biological tissue. In recent years there have been several reports on NIR-excitable upconverting nanoparticles capable of working in biological mixtures and cellular settings. Unfortunately, most of these nanosystems are based on ytterbium's upconversion at 980 nm, concurrent with water's absorption within the first biological window. Thus, methods to produce robust upconverting nanoplatforms that ca

SUBMITTER: Martinez R 

PROVIDER: S-EPMC7275415 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature