Prostate-specific membrane antigen (PSMA) expression in adenoid cystic carcinoma of the head and neck.

ABSTRACT:

Background

Treatment options for advanced head and neck adenoid cystic carcinoma (AdCC) are limited. Prostate-Specific Membrane Antigen (PSMA), a transmembrane protein that is known for its use in diagnostics and targeted therapy in prostate cancer, is also expressed by AdCC. This study aimed to analyse PSMA expression in a large cohort of primary, recurrent and metastasized AdCC of the head and neck.

Methods

One hundred ten consecutive patients with histologically confirmed AdCC in the period 1990-2017 were included. An analysis was made of clinical details, revised pathology and semiquantitative immunohistochemical expression of PSMA on tissue microarray and whole slides. Associations of PSMA expression with clinicopathological parameters were explored and survival was ana

SUBMITTER: Klein Nulent TJW 

PROVIDER: S-EPMC7275445 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature