Parenteral thiamine for prevention and treatment of delirium in critically ill adults: a systematic review protocol.

ABSTRACT:

Background

Delirium is an acute confusional state, common in critical illness and associated with cognitive decline. There is no effective pharmacotherapy to prevent or treat delirium, although it is scientifically plausible that thiamine could be effective. Thiamine studies in dementia patients are inconclusive. Aside from small numbers, all used oral administration: bioavailability of thiamine is poor; parenteral thiamine bypasses this. In the UK, parenteral thiamine is administered as a compound vitamin B and C solution (Pabrinex®). The aim of this review is to evaluate the effectiveness of parenteral thiamine (alone or in a compound solution) in preventing or treating delirium in critical illness.

Methods

We will search for studies in electronic databases (MEDLINE (Pro-Q

SUBMITTER: McKenzie CA 

PROVIDER: S-EPMC7275448 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature