Immunopathology in schistosomiasis is regulated by TLR2,4- and IFN-γ-activated MSC through modulating Th1/Th2 responses.

ABSTRACT:

Background and aims

A marked egg-induced CD4⁺ T cell programmed inflammation and subsequent hepatic fibrosis characterize the pathogenesis of schistosomiasis. Mesenchymal stem cell (MSC) has been extensively studied for the treatment of schistosomiasis. However, the mechanism by which MSCs modulate the pathogenesis of schistosomiasis has not been clarified. Furthermore, the local inflammatory milieu may greatly influence the immunoregulatory properties of MSCs, and our early experiments demonstrated that Toll-like receptor (TLR)2/TLR4 agonist effected immune modulation of MSC. Here, we further investigated their modulation on the pathogenesis of schistosomiasis.

Methods

Adult BALB/c male mice were percutaneously infected with 16 ± 2 pairs S. japonicum cercariae an

SUBMITTER: Liu C 

PROVIDER: S-EPMC7275460 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature