CTCF loss mediates unique DNA hypermethylation landscapes in human cancers.

ABSTRACT:

Background

The chromatin insulator CCCTC-binding factor (CTCF) displays tissue-specific DNA binding sites that regulate transcription and chromatin organization. Despite evidence linking CTCF to the protection of epigenetic states through barrier insulation, the impact of CTCF loss on genome-wide DNA methylation sites in human cancer remains undefined.

Results

Here, we demonstrate that prostate and breast cancers within The Cancer Genome Atlas (TCGA) exhibit frequent copy number loss of CTCF and that this loss is associated with increased DNA methylation events that occur preferentially at CTCF binding sites. CTCF sites differ among tumor types and result in tissue-specific methylation patterns with little overlap between breast and prostate cancers. DNA methylation and tran

SUBMITTER: Damaschke NA 

PROVIDER: S-EPMC7275597 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature