Sex differences in pharmacokinetics predict adverse drug reactions in women.

ABSTRACT:

Background

Women experience adverse drug reactions, ADRs, nearly twice as often as men, yet the role of sex as a biological factor in the generation of ADRs is poorly understood. Most drugs currently in use were approved based on clinical trials conducted on men, so women may be overmedicated. We determined whether sex differences in drug pharmacokinetics, PKs, predict sex differences in ADRs.

Methods

Searches of the ISI Web of Science and PubMed databases were conducted with combinations of the terms: drugs, sex or gender, pharmacokinetics, pharmacodynamics, drug safety, drug dose, and adverse drug reaction, which yielded over 5000 articles with considerable overlap. We obtained information from each relevant article on significant sex differences in PK measures, predominan

SUBMITTER: Zucker I 

PROVIDER: S-EPMC7275616 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature