In silico Evaluation of PLAC1-fliC As a Chimeric Vaccine against Breast Cancer

ABSTRACT:

Background

Breast cancer is one of the most prevalent cancers among women. Common cancer treatment methods are not effective enough, and there is a need for a more efficient treatment procedure. Cancer vaccine is a novel immunotherapy method that stimulates humoral and/or cellular immunity against cancer. Placenta-specific protein 1 (PLAC1) is a cancer/testis antigen, prevalent in breast cancer and rarely found in normal tissues. FliC, as a bacterial adjuvant, when fused to PLAC1 can elicit humoral and cellular responses. Therefore, PLAC1-fliC is a chimeric protein, which can be considered a suitable candidate against breast cancer.

Methods

ProtParam was used to evaluate the physicochemical properties of PLAC1-fliC. Second structures were determined using the GOR V server. P

SUBMITTER: Taheri-Anganeh M 

PROVIDER: S-EPMC7275624 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature