Dexmedetomidine extraction by the extracorporeal membrane oxygenation circuit: results from an in vitro study.

ABSTRACT:

Background

Dexmedetomidine is a sedative administered to minimize distress and decrease the risk of life threatening complications in children supported with extracorporeal membrane oxygenation. The extracorporeal membrane oxygenation circuit can extract drug and decrease drug exposure, placing the patient at risk of therapeutic failure.

Objective

To determine the extraction of dexmedetomidine by the extracorporeal membrane oxygenation circuit.

Materials and methods

Dexmedetomidine was studied in three closed-loop circuit configurations to isolate the impact of the oxygenator, hemofilter, and tubing on circuit extraction. Each circuit was primed with human blood according to standard practice for Duke Children's Hospital, and flow was set to 1 L/min. Dexmedetomidine w

SUBMITTER: Dallefeld SH 

PROVIDER: S-EPMC7275646 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature