The effect of journal guidelines on the reporting of antibody validation.

ABSTRACT:

Background

Despite the widespread use of antibodies as a research tool, problems with specificity, lot-to-lot consistency and sensitivity commonly occur and may be important contributing factors to the 'replication crisis' in biomedical research. This makes the validation of antibodies and accurate reporting of this validation in the scientific literature extremely important. Therefore, some journals now require authors to comply with antibody reporting guidelines.

Methods

We used a quasi-experimental approach to assess the effectiveness of such journal guidelines in improving antibody reporting in the scientific literature. In a sample of 120 publications, we compared the reporting of antibody validation and identification information in two journals with guidelines (Nat

SUBMITTER: Hoek JM 

PROVIDER: S-EPMC7275675 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature