Identification of DEGs and transcription factors involved in H. pylori-associated inflammation and their relevance with gastric cancer.

ABSTRACT:

Background

Previous studies have indicated that chronic inflammation linked to H. pylori infection is the leading causes for gastric cancer (GC). However, the exact mechanism is not entirely clear until now.

Purpose

To identify the key molecules and TFs involved in H. pylori infection and to provide new insights into H. pylori-associated carcinogenesis and lay the groundwork for the prevention of GC.

Results

GO and KEGG analysis revealed that the DEGs of Hp⁺-NAG were mainly associated with the immune response, chemokine activity, extracellular region and rheumatoid arthritis pathway. The DEGs of Hp⁺-AG-IM were related to the apical plasma membrane, intestinal cholesterol absorption, transporter activity and fat digestion and

SUBMITTER: Yin H 

PROVIDER: S-EPMC7275685 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature