Host nutrient milieu drives an essential role for aspartate biosynthesis during invasive Staphylococcus aureus infection.

ABSTRACT: The bacterial pathogen Staphylococcus aureus is capable of infecting a broad spectrum of host tissues, in part due to flexibility of metabolic programs. S. aureus, like all organisms, requires essential biosynthetic intermediates to synthesize macromolecules. We therefore sought to determine the metabolic pathways contributing to synthesis of essential precursors during invasive S. aureus infection. We focused specifically on staphylococcal infection of bone, one of the most common sites of invasive S. aureus infection and a unique environment characterized by dynamic substrate accessibility, infection-induced hypoxia, and a metabolic profile skewed toward aerobic glycolysis. Using a murine model of osteomyelitis, we examined survival of S. aureus mutants deficient in central metabolic pat

SUBMITTER: Potter AD 

PROVIDER: S-EPMC7275739 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature