HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation.

ABSTRACT: A cure for HIV-1 remains unattainable as only one case has been reported, a decade ago^1,2. The individual-who is known as the 'Berlin patient'-underwent two allogeneic haematopoietic stem-cell transplantation (HSCT) procedures using a donor with a homozygous mutation in the HIV coreceptor CCR5 (CCR5Δ32/Δ32) to treat his acute myeloid leukaemia. Total body irradiation was given with each HSCT. Notably, it is unclear which treatment or patient parameters contributed to this case of long-term HIV remission. Here we show that HIV-1 remission may be possible with a less aggressive and toxic approach. An adult infected with HIV-1 underwent allogeneic HSCT for Hodgkin's lymphoma using cells from a CCR5Δ32/Δ32 donor. He experienced mild gut graft-versus-host disease. Antiretroviral ther

SUBMITTER: Gupta RK 

PROVIDER: S-EPMC7275870 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature