Association of population mixing and acute lymphocytic leukemia in children and young adults.

ABSTRACT:

Background

The association of population mixing (PM¹) with childhood acute lymphocytic leukemia (ALL²) has been reproduced in multiple studies. However, the mechanism underlying this association is unknown.

Methods

Ecological study of incidence of pediatric ALL among 253 counties in the State of Texas (USA) using surrogates of genetic and environmental PM. ALL incidence data were obtained from Texas Cancer Registry and county population statistics from the US Census Bureau. Poisson regression was used to compare ALL incidence and PM.

Results

There is substantial and variable genetic and environmental PM among counties in Texas. Indicators of genetic PM including proportion of multiracial households, ratio of Hispanics to non-Hispanics, and ratio

SUBMITTER: Lubega J 

PROVIDER: S-EPMC7275880 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature