Histology of the Cochlear Outer Sulcus Cells in Normal Human Ears, Presbycusis, and Meniere's Disease.

ABSTRACT:

Hypothesis

Outer sulcus cell features and distribution are hypothesized to differ throughout regions of the human cochlea and between diseased and normal specimens.

Background

Outer sulcus cells play a role in inner ear fluid homeostasis. However, their anatomy and distribution in the human are not well described.

Methods

Temporal bone specimens with normal hearing (n = 10), Menière's disease (n = 10), presbycusis with flat audiograms (n = 4), and presbycusis with sloping audiograms (n = 5) were examined by light microscopy. Outer sulcus cells were assessed quantitatively and qualitatively in each cochlear turn. One specimen was stained for tubulin immunofluorescence and imaged using confocal microscopy.

Results

Outer sulcus cells interface with endolymph throu

SUBMITTER: Christov F 

PROVIDER: S-EPMC7275934 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature