Innate and adaptive immune cell subsets as risk factors for coronary heart disease in two population-based cohorts.

ABSTRACT:

Background and aims

Cell-mediated immunity is implicated in atherosclerosis. We evaluated whether innate and adaptive immune cell subsets in peripheral blood are risk factors for coronary heart disease.

Methods

A nested case-cohort study (n = 2155) was performed within the Multi-Ethnic Study of Atherosclerosis (MESA) and the Cardiovascular Health Study (CHS). Cases of incident myocardial infarction (MI) and incident angina (n = 880 total cases) were compared with a cohort random sample (n = 1275). Immune cell phenotypes (n = 34, including CD14⁺ monocytes, natural killer cells, γδ T cells, CD4⁺, CD8⁺ and CD19⁺ lymphocyte subsets) were measured from cryopreserved cells by flow cytometry. Cox proportional hazards models with adjustmen

SUBMITTER: Olson NC 

PROVIDER: S-EPMC7276206 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature