Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients.
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ABSTRACT:
SUBMITTER: Suthar MS
PROVIDER: S-EPMC7276302 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Rapid Generation of Neutralizing Antibody Responses in COVID-19 Patients.
Suthar Mehul S MS Zimmerman Matthew G MG Kauffman Robert C RC Mantus Grace G Linderman Susanne L SL Hudson William H WH Vanderheiden Abigail A Nyhoff Lindsay L Davis Carl W CW Adekunle Oluwaseyi O Affer Maurizio M Sherman Melanie M Reynolds Stacian S Verkerke Hans P HP Alter David N DN Guarner Jeannette J Bryksin Janetta J Horwath Michael C MC Arthur Connie M CM Saakadze Natia N Smith Geoffrey H GH Edupuganti Srilatha S Scherer Erin M EM Hellmeister Kieffer K Cheng Andrew A Morales Juliet A JA Neish Andrew S AS Stowell Sean R SR Frank Filipp F Ortlund Eric E Anderson Evan J EJ Menachery Vineet D VD Rouphael Nadine N Mehta Aneesh K AK Stephens David S DS Ahmed Rafi R Roback John D JD Wrammert Jens J
Cell reports. Medicine 20200608 3
SARS-CoV-2, the virus responsible for COVID-19, is causing a devastating worldwide pandemic, and there is a pressing need to understand the development, specificity, and neutralizing potency of humoral immune responses during acute infection. We report a cross-sectional study of antibody responses to the receptor-binding domain (RBD) of the spike protein and virus neutralization activity in a cohort of 44 hospitalized COVID-19 patients. RBD-specific IgG responses are detectable in all patients 6 ...[more]
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