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Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report.

ABSTRACT: Pazopanib, a multityrosine kinase inhibitor used for treating malignant soft tissue tumors, rarely causes adverse events associated with the respiratory system. We report a case of a 73-year-old male with leiomyosarcoma treated with pazopanib. Four months after treatment initiation, chest computed tomography showed bilateral patchy consolidation and ground-glass opacities. Bronchoscopy revealed increased lymphocytes in the bronchoalveolar lavage fluid. Histological analysis of lung tissue demonstrated intraluminal fibrotic changes in alveolar spaces. According to these findings, we diagnosed the patient with pazopanib-induced organizing pneumonia. To best of our knowledge, this is the first report of such a case.

SUBMITTER: Watanabe C 

PROVIDER: S-EPMC7276494 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Pazopanib-induced organizing pneumonia in a patient with leiomyosarcoma: A case report.

Watanabe Chie C   Miyata Jun J   Esaki Kotoba K   Suematsu Ryohei R   Sano Tomoya T   Yamamoto Takayuki T   Sasaki Hisashi H   Maki Yohei Y   Tagami Yoichi Y   Kimizuka Yoshifumi Y   Fujikura Yuji Y   Ito Keiichi K   Kawana Akihiko A  

Respiratory medicine case reports 20200531

Pazopanib, a multityrosine kinase inhibitor used for treating malignant soft tissue tumors, rarely causes adverse events associated with the respiratory system. We report a case of a 73-year-old male with leiomyosarcoma treated with pazopanib. Four months after treatment initiation, chest computed tomography showed bilateral patchy consolidation and ground-glass opacities. Bronchoscopy revealed increased lymphocytes in the bronchoalveolar lavage fluid. Histological analysis of lung tissue demons  ...[more]

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