Effect of continuous positive airway pressure treatment on permeability, inflammation and mucus production of human epithelial cells.

ABSTRACT: Continuous positive airway pressure (CPAP) therapy is the gold standard treatment for obstructive sleep apnoea, which affects millions of people worldwide. However, this therapy normally results in symptoms such as dryness, sneezing, rhinorrhoea, post-nasal drip, nasal congestion and epistaxis in the upper airways. Using bronchial epithelial (Calu-3) and nasal epithelial (RPMI 2650) cells in an in vitro respiratory model, this study, for the first time, investigates the effect of CPAP positive pressure on the human respiratory epithelial mechanisms that regulate upper airways lubrication characteristics. To understand how the epithelium and mucus are affected by this therapy, several parameters were determined before and after positive pressure application. This work demonstrates that the

SUBMITTER: Grau-Bartual S 

PROVIDER: S-EPMC7276533 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature