Real-time toxicity prediction of Aconitum stewing system using extractive electrospray ionization mass spectrometry.

ABSTRACT: Due to numerous obstacles such as complex matrices, real-time monitoring of complex reaction systems (e.g., medicinal herb stewing system) has always been a challenge though great values for safe and rational use of drugs. Herein, facilitated by the potential ability on the tolerance of complex matrices of extractive electrospray ionization mass spectrometry, a device was established to realize continuous sampling and real-time quantitative analysis of herb stewing system for the first time. A complete analytical strategy, including data acquisition, data mining, and data evaluation was proposed and implemented with overcoming the usual difficulties in real-time mass spectrometry quantification. The complex Fuzi (the lateral root of Aconitum)-meat stewing systems were real-ti

SUBMITTER: Qiu ZD 

PROVIDER: S-EPMC7276682 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature