Berberine prevents primary peritoneal adhesion and adhesion reformation by directly inhibiting TIMP-1.

ABSTRACT: Peritoneal adhesions are fibrous tissues that tether organs to one another or to the peritoneal wall and represent the major cause of postsurgical morbidity. Enterolysis at repeat surgeries induces adhesion reformation that is more difficult to prevent than primary adhesion. Here we studied the preventive effects of different approaches of berberine treatment for primary adhesion, and its effects on adhesion reformation compared to Interceed. We found the primary adhesion was remarkably prevented by berberine through intraperitoneal injection 30 min before abrasive surgery (pre-berberine) or direct addition into injured cecum immediately after the surgery (inter-berberine). Rats with adhesion reformation had a more deteriorative collagen accumulation and tissue injury in abrasive sites tha

SUBMITTER: Liu X 

PROVIDER: S-EPMC7276697 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature