Treatment with Hydroxychloroquine vs Hydroxychloroquine + Nitazoxanide in COVID-19 patients with risk factors for poor prognosis: A structured summary of a study protocol for a randomised controlled trial.

ABSTRACT:

Objectives

To determine the efficacy of Hydroxychloroquine vs. Hydroxychloroquine + Nitazoxanide in reducing the need for invasive mechanical ventilatory support for patients with COVID-19. Hydroxychloroquine is currently being used in multiple trials with varying doses in an attempt to treat COVID-19. Nitazoxanide has powerful antiviral effects and proven efficacy against a range of viruses including SARS and MERS. Dual therapy by combining appropriate doses of these two medications with diverse activities against COVID-19 is expected to be better than monotherapy with hydroxychloroquine.

Trial design

This is a single centre, randomized, controlled, single blinded, 2 arm (ratio 1:1) parallel group trial.

Participants

86 COVID-19 positive patients that are being treat

SUBMITTER: Calderon JM 

PROVIDER: S-EPMC7276957 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature