Intracranial-to-central venous pressure gap predicts the responsiveness of intracranial pressure to PEEP in patients with traumatic brain injury: a prospective cohort study.

ABSTRACT:

Background

Mechanical ventilation (MV) with positive end-expiratory pressure (PEEP) is commonly applied in patients with severe traumatic brain injury (sTBI). However, the individual responsiveness of intracranial pressure (ICP) to PEEP varies. Thus, identifying an indicator detecting ICP responsiveness to PEEP is of great significance. As central venous pressure (CVP) could act as an intermediary to transduce pressure from PEEP to ICP, we developed a new indicator, P_ICGap, representing the gap between baseline ICP and baseline CVP. The aim of the current study was to explore the relationship between P_ICGap and ICP responsiveness to PEEP.

Methods

A total of 112 patients with sTBI undergoing MV were enrolled in this prospective cohort study. ICP, CVP, ce

SUBMITTER: Li HP 

PROVIDER: S-EPMC7276961 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature