Construction and forensic application of 20 highly polymorphic microhaplotypes.

ABSTRACT: Microhaplotype markers have become an important research focus in forensic genetics. However, many reported microhaplotype markers have limited polymorphisms. In this study, we developed a set of highly polymorphic microhaplotype markers based on tri-allelic single-nucleotide polymorphisms. Eleven newly discovered microhaplotypes along with nine previously identified in our laboratory were studied. The microhaplotype genotypes of unrelated individuals and familial samples were generated on the MiSeq PE300 platform. These 20 loci have an average greater than 3.5 effective number of alleles. Over the whole set, the cumulative power of discrimination was 1-3.3 × 10^-18, the cumulative power of exclusion was 1-1.928 × 10^-7 and the theoretical probability of detecting a mix

SUBMITTER: Kureshi A 

PROVIDER: S-EPMC7277291 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature