Helium-Oxygen Mixture Model for Particle Transport in CT-Based Upper Airways.

ABSTRACT: The knowledge of respiratory particle transport in the extra-thoracic pathways is essential for the estimation of lung health-risk and optimization of targeted drug delivery. The published literature reports that a significant fraction of the inhaled aerosol particles are deposited in the upper airways, and available inhalers can deliver only a small amount of drug particles to the deeper airways. To improve the targeted drug delivery efficiency to the lungs, it is important to reduce the drug particle deposition in the upper airways. This study aims to minimize the unwanted aerosol particle deposition in the upper airways by employing a gas mixture model for the aerosol particle transport within the upper airways. A helium-oxygen (heliox) mixture (80% helium and 20% oxygen) model is devel

SUBMITTER: Islam MS 

PROVIDER: S-EPMC7277378 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature