Sex Differences in Biological Processes and Nitrergic Signaling in Mouse Brain.

ABSTRACT: Nitric oxide (NO) represents an important signaling molecule which modulates the functions of different organs, including the brain. S-nitrosylation (SNO), a post-translational modification that involves the binding of the NO group to a cysteine residue, is a key mechanism of nitrergic signaling. Most of the experimental studies are carried out on male animals. However, significant differences exist between males and females in the signaling mechanisms. To investigate the sex differences in the SNO-based regulation of biological functions and signaling pathways in the cortices of 6-8-weeks-old mice, we used the mass spectrometry technique, to identify S-nitrosylated proteins, followed by large-scale computational biology. This work revealed significant sex differences in the NO and SNO-rel

SUBMITTER: Khaliulin I 

PROVIDER: S-EPMC7277573 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature