Mining Drug-Target Associations in Cancer: Analysis of Gene Expression and Drug Activity Correlations.

ABSTRACT: Cancer is a complex disease affecting millions of people worldwide, with over a hundred clinically approved drugs available. In order to improve therapy, treatment, and response, it is essential to draw better maps of the targets of cancer drugs and possible side interactors. This study presents a large-scale screening method to find associations of cancer drugs with human genes. The analysis is focused on the current collection of Food and Drug Administration (FDA)-approved drugs (which includes about one hundred chemicals). The approach integrates global gene-expression transcriptomic profiles with drug-activity profiles of a set of 60 human cell lines obtained for a collection of chemical compounds (small bioactive molecules). Using a standardized expression for each gene versus standar

SUBMITTER: Arroyo MM 

PROVIDER: S-EPMC7277587 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature