Possible Adverse Effects of High-Dose Nicotinamide: Mechanisms and Safety Assessment.

ABSTRACT: Nicotinamide (NAM) at doses far above those recommended for vitamins is suggested to be effective against a wide spectrum of diseases and conditions, including neurological dysfunctions, depression and other psychological disorders, and inflammatory diseases. Recent increases in public awareness on possible pro-longevity effects of nicotinamide adenine dinucleotide (NAD+) precursors have caused further growth of NAM consumption not only for clinical treatments, but also as a dietary supplement, raising concerns on the safety of its long-term use. However, possible adverse effects and their mechanisms are poorly understood. High-level NAM administration can exert negative effects through multiple routes. For example, NAM by itself inhibits poly(ADP-ribose) polymerases (PARPs), which protect

SUBMITTER: Hwang ES 

PROVIDER: S-EPMC7277745 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature