Longitudinal changes in glucose metabolism in women with gestational diabetes, from late pregnancy to the postpartum period.

ABSTRACT:

Aims/hypothesis

This study aimed to determine, in women with gestational diabetes (GDM), the changes in insulin sensitivity (Matsuda Insulin Sensitivity Index; IS_OGTT), insulin response and disposition index (DI) from late pregnancy (34-37 weeks gestation, T1), to early postpartum (1-5 days, T2) and late postpartum (6-12 weeks, T3). A secondary aim was to correlate the longitudinal changes in maternal lipids, adipokines, cytokines and weight in relation to the changes in IS_OGTT, insulin response and DI.

Methods

IS_OGTT, insulin response and DI were calculated at the three time points (T1, T2 and T3) using the results of a 75 g OGTT. Adipokines, cytokines and lipids were measured prior to each OGTT. Linear mixed-effects models were used to comp

SUBMITTER: Waters TP 

PROVIDER: S-EPMC7277959 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature