Maintenance of skeletal muscle function following reduced daily physical activity in healthy older adults: a pilot trial.

ABSTRACT: Older adults can experience periods of inactivity related to disease or illness, which can hasten the development of physical disability, in part, through reductions in skeletal muscle strength and power. To date no study has characterized adaptations in skeletal muscle physical function in response to reduced daily physical activity. Participants (15 men, aged 69 ± 2 years; 15 women, aged 68 ± 4 years) restricted their daily steps (<750 steps/day) while being energy restricted (-500 kcal/day) for 2 weeks before returning to normal activity levels during recovery (RC; 1 week). Before and after each phase, measures of knee extensor isometric maximum voluntary contraction (MVC), time-to-peak torque, and physical function were performed and muscle biopsies were taken from a subset of particip

SUBMITTER: Oikawa SY 

PROVIDER: S-EPMC7278031 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature