Survival after hypofractionation in glioblastoma: a systematic review and meta-analysis.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) has a poor prognosis despite a multi modal treatment that includes normofractionated radiotherapy. So, various hypofractionated alternatives to normofractionated RT have been tested to improve such prognosis. There is need of systematic review and meta-analysis to analyse the literature properly and maybe generalised the use of hypofractionation. The aim of this study was first, to perform a meta-analysis of all controlled trials testing the impact of hypofractionation on survival without age restriction and secondly, to analyse data from all non-comparative trials testing the impact of hypofractionation, radiosurgery and hypofractionated stereotactic RT in first line.

Materials/methods

We searched Medline, Embase and Cochrane databas

SUBMITTER: Trone JC 

PROVIDER: S-EPMC7278121 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature