Advanced stratification analyses in molecular association meta-analysis: methodology and application.

ABSTRACT:

Background

Stratification analyses have been widely utilized in molecular association meta-analyses to estimate the interaction between genetic and environmental factors or to control for the confounding variables linked to a disease. Two calculation methods utilized in practical research, which are known as the variants of factorial stratification analysis and confounder-controlling stratification analysis in our nomenclature, have been applied in previous studies, but none of which have presented a methodology and application for these analyses.

Methods

In this paper, these two approaches are integrated and further developed into a standard procedure for stratification analysis. We first propose the advanced statistical methodology and theoretical algorithm of these three

SUBMITTER: Lin S 

PROVIDER: S-EPMC7278161 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature