Prenatal exposure to pesticides and risk for holoprosencephaly: a case-control study.

ABSTRACT:

Background

Pesticide exposure during susceptible windows and at certain doses are linked to numerous birth defects. Early experimental evidence suggests an association between active ingredients in pesticides and holoprosencephaly (HPE), the most common malformation of the forebrain in humans (1 in 250 embryos). No human studies to date have examined the association. This study investigated pesticides during multiple windows of exposure and fetal risk for HPE. It is hypothesized that pre-conception and early pregnancy, the time of brain development in utero, are the most critical windows of exposure.

Methods

A questionnaire was developed for this retrospective case-control study to estimate household, occupational, and environmental pesticide exposures. Four windows of expos

SUBMITTER: Addissie YA 

PROVIDER: S-EPMC7278164 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature