Internalization and Viability Studies of Suspended Nanowire Silicon Chips in HeLa Cells.

ABSTRACT: Micrometer-sized silicon chips have been demonstrated to be cell-internalizable, offering the possibility of introducing in cells even smaller nanoelements for intracellular applications. On the other hand, silicon nanowires on extracellular devices have been widely studied as biosensors or drug delivery systems. Here, we propose the integration of silicon nanowires on cell-internalizable chips in order to combine the functional features of both approaches for advanced intracellular applications. As an initial fundamental study, the cellular uptake in HeLa cells of silicon 3 µm × 3 µm nanowire-based chips with two different morphologies was investigated, and the results were compared with those of non-nanostructured silicon chips. Chip internalization without affecting cell viability was a

SUBMITTER: Duran S 

PROVIDER: S-EPMC7279308 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature