Effects of FTMT Expression by Retinal Pigment Epithelial Cells on Features of Angiogenesis.

ABSTRACT: Aberrant angiogenesis is a pathological feature of a number of diseases and arises from the uncoordinated expression of angiogenic factors as response to different cellular stresses. Age-related macular degeneration (AMD), a leading cause of vision loss, can result from pathological angiogenesis. As a mutation in the mitochondrial ferritin (FTMT) gene has been associated with AMD, its possible role in modulating angiogenic factors and angiogenesis was investigated. FTMT is an iron-sequestering protein primarily expressed in metabolically active cells and tissues with high oxygen demand, including retina. In this study, we utilized the human retinal pigment epithelial cell line ARPE-19, both as undifferentiated and differentiated cells. The effects of proinflammatory cytokines, FTMT knockdo

SUBMITTER: Buyandelger U 

PROVIDER: S-EPMC7279371 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature