IPSCs from people with MS can differentiate into oligodendrocytes in a homeostatic but not an inflammatory milieu.

ABSTRACT: Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS) that results in variable severities of neurodegeneration. The understanding of MS has been limited by the inaccessibility of the affected cells and the lengthy timeframe of disease development. However, recent advances in stem cell technology have facilitated the bypassing of some of these challenges. Towards gaining a greater understanding of the innate potential of stem cells from people with varying degrees of disability, we generated induced pluripotent stem cells (iPSCs) from peripheral blood mononuclear cells derived from stable and progressive MS patients, and then further differentiated them into oligodendrocyte (OL) lineage cells. We analyzed differentiation under both homeosta

SUBMITTER: Morales Pantoja IE 

PROVIDER: S-EPMC7279569 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature