Molecular dissection of Chagas induced cardiomyopathy reveals central disease associated and druggable signaling pathways.

ABSTRACT: Chagas disease, the clinical presentation of T. cruzi infection, is a major human health concern. While the acute phase of Chagas disease is typically asymptomatic and self-resolving, chronically infected individuals suffer numerous sequelae later in life. Cardiomyopathies in particular are the most severe consequence of chronic Chagas disease and cannot be reversed solely by parasite load reduction. To prioritize new therapeutic targets, we unbiasedly interrogated the host signaling events in heart tissues isolated from a Chagas disease mouse model using quantitative, multiplexed proteomics. We defined the host response to infection at both the proteome and phospho-proteome levels. The proteome showed an increase in the immune response and a strong repression of several mitochondrial prot

SUBMITTER: Wozniak JM 

PROVIDER: S-EPMC7279607 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature