Combination checkpoint blockade for metastatic cutaneous malignancies in kidney transplant recipients.

ABSTRACT:

Background

Immune checkpoint blockade has emerged as a highly effective treatment for patients with metastatic melanoma and cutaneous squamous cell carcinoma. Nivolumab blocks the interactions between programmed cell death protein 1 and programmed death ligand 1 allowing for activation of a latent immune response against the malignancy. Ipilimumab binds to and blocks cytotoxic T-lymphocyte-associated protein 4, alleviating the negative regulation of T-cell activation that is mediated by that checkpoint. Combination therapy with nivolumab and ipilimumab is associated with longer overall survival at 5 years compared with nivolumab monotherapy. Solid organ transplant recipients have a significantly higher risk of malignancies compared with the general population. There is limited data

SUBMITTER: Trager MH 

PROVIDER: S-EPMC7279669 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature