Significant Association of Interleukin-16 Genetic Variations to Taiwanese Lung Cancer.

ABSTRACT:

Background/aim

Interleukin-16 has been reported to exhibit tumoricidal effects, however, the contribution of IL-16 genotypes to lung cancer is still largely unrevealed. This study aimed at investigating whether IL-16 genotypes contribute to lung cancer susceptibility.

Materials and methods

IL-16 rs4778889, rs11556218, and rs4072111 genotypic characteristics were determined among 358 lung cancer patients and 716 controls via the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) methodology.

Results

The highlight finding is that the distributions of genotypic (p=8.6E-10) and allelic (p=0.0001) frequencies of IL-16 rs11556218 was significantly different between cases and controls. In detail, the frequencies of IL-16 rs11556218 heterozygo

SUBMITTER: Wu MF 

PROVIDER: S-EPMC7279827 | biostudies-literature | 2020 May-Jun

REPOSITORIES: biostudies-literature