Low-level X Chromosome Mosaicism: A Common Finding in Women Undergoing IVF.

ABSTRACT:

Background/aim

To determine the incidence of X chromosome mosaicism in women undergoing in vitro fertilization (IVF) treatment and present preimplantation genetic testing for aneuploidy (PGT-A) outcome of this group.

Patients and methods

A total of 1,058 women undergoing IVF and 154 women with no fertility problems were enrolled in the study. Karyotyping from peripheral blood lymphocytes was performed by conventional cytogenetics. Twenty-nine women with X mosaicism underwent PGT-A by array-comparative genomic hybridization from embryos at the blastocyst stage.

Results and conclusion

Out of 1,058 women undergoing IVF, 166 (15.7%) had an abnormal karyotype. The most common finding (14.6%) was X chromosome mosaicism. Its frequency was higher in women >35 years old and re

SUBMITTER: Zachaki S 

PROVIDER: S-EPMC7279861 | biostudies-literature | 2020 May-Jun

REPOSITORIES: biostudies-literature