Intraocular pressure fluctuation and neurodegeneration in the diabetic rat retina.

ABSTRACT:

Background and purpose

Early retinal neurodegeneration occurs as one of the complications of diabetes even before clinically detectable diabetic vascular retinopathy. The pathogenesis of retinal diabetic neuropathy is still not well understood. We investigated the serial changes or fluctuations in intraocular pressure (IOP) and examined their roles in the pathogenesis of neuronal degeneration in diabetic retina.

Experimental approach

Male Sprague Dawley rats with streptozotocin-induced diabetes were treated with ophthalmic preparations of brinzolamide, latanoprost, both drugs (combined treatment) or saline for 8 weeks. IOP was measured daily under general anaesthesia using a rebound tonometer. Antegrade axoplasmic flow in the optic nerve was assessed with a fluorescent subst

SUBMITTER: Jung KI 

PROVIDER: S-EPMC7279969 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature