Cannabidiol protects against high glucose-induced oxidative stress and cytotoxicity in cardiac voltage-gated sodium channels.

ABSTRACT:

Background and purpose

Cardiovascular complications are the major cause of mortality in diabetic patients. However, the molecular mechanisms underlying diabetes-associated arrhythmias are unclear. We hypothesized that high glucose could adversely affect Na_v 1.5, the major cardiac sodium channel isoform of the heart, at least partially via oxidative stress. We further hypothesized that cannabidiol (CBD), one of the main constituents of Cannabis sativa, through its effects on Na_v 1.5, could protect against high glucose-elicited oxidative stress and cytotoxicity.

Experimental approach

To test these ideas, we used CHO cells transiently co-transfected with cDNA encoding human Na_v 1.5 α-subunit under control and high glucose conditions (50 or 100 m

SUBMITTER: Fouda MA 

PROVIDER: S-EPMC7279989 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature