Clinicopathologic correlates of MYD88 L265P mutation and programmed cell death (PD-1) pathway in primary central nervous system lymphoma.

ABSTRACT: Primary central nervous system lymphoma (PCNSL) patients have a poorer prognosis than systemic lymphoma. Gain-of-function MYD88 c.794T > C (p. L265P) mutation and programed cell death-1 (PD-1) pathway alterations are potential targetable pathways. Our study objective was to determine the clinicopathologic correlates of MYD88 mutation and PD-1 alterations in PCNSL and the impact of Epstein-Barr virus (EBV) infection. We studied 53 cases including 13 EBV-associated (EBV^pos) PCNSL, 49% harbored MYD88 mutation, none seen in EBV^pos PCNSL. MYD88 protein expression did not correlate with MYD88 mutation. T-cell and macrophage infiltration was common. All PD-L1-positive tumors were EBV^pos. Two PD-L1 positive tumors showed 9p24.1/PD-L1 loc

SUBMITTER: Sethi TK 

PROVIDER: S-EPMC7280020 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature