Variations Between Dose-Ventilation and Dose-Perfusion Metrics in Radiation Therapy Planning for Lung Cancer.

ABSTRACT:

Purpose

Currently, several active clinical trials of functional lung avoidance radiation therapy using different imaging modalities for ventilation or perfusion are underway. Patients with lung cancer often show ventilation-perfusion mismatch, whereas the significance of dose-function metric remains unclear. The aim of the present study was to compare dose-ventilation metrics with dose-perfusion metrics for radiation therapy plan evaluation.

Methods and materials

Pretreatment 4-dimensional computed tomography and ^99mTc-macroaggregated albumin single-photon emission computed tomography perfusion images of 60 patients with lung cancer treated with radiation therapy were analyzed. Ventilation images were created using the deformable image registration of 4-dimensiona

SUBMITTER: Nakajima Y 

PROVIDER: S-EPMC7280081 | biostudies-literature | 2020 May-Jun

REPOSITORIES: biostudies-literature